Disulfiram and How It Works

Disulfiram is the first and still most recommended drug approved worldwide for alcoholism treatment. Opposite to new medicines for addiction to alcohol that either minimize the effects of spirits’ consumption (Revia and Vivitrol) or partially or entirely terminates an urge to consume alcohol beverage (naltrexone), Disulfiram makes individuals feel enormously ill and uncomfortable if they consume any form of alcohol.

The well-known in medicine and pharmacy disulfiram-ethanol reaction (DER) manifests by the following symptoms:

• a severe headache,
• seizures,
• sweeping reddening and hot flushing,
• sickness,
• dyspnea,
• tremors,
• shakes,
• nausea and vomiting,
• tachycardia with arrhythmia and extrasystoles,
• hypotension, dizziness and tendency to pass out.

During clinical studies in most severe cases, DER caused even acute circulatory failure. However, the mortality rate reported way below 0.05%.

Unfortunately, both Naltrexone and Antabuse aka Disulfiram may lead to tiredness, anorexia, depression, erectile dysfunction, peripheral neuritis, neuropathies, shakings, and phobias even without reaction with alcohol.

Disulfiram Taken Orally

The medicine Disulfiram (Antabuse) recommended for PO administration. A daily prescription of 200 mg commonly delivers a strong reaction if the patient consumes any amount of spirits. The effect of one dose of the Antabuse usually lasts for 2-3 days.